The Hyperactivation of JAK-STAT Signaling Connects Inborn Errors of Immunity and Autoimmune Diseases

The Hyperactivation of JAK-STAT Signaling Connects Inborn Errors of Immunity and Autoimmune Diseases

Blog Article

JAK-STAT signaling pathway is an important cytokine signaling transduction pathway.Many monogenic loss-of-function or gain-of-function mutations in this pathway can cause inborn errors of immunity (IEI).Autoimmune diseases are caused by polygenic and different factors.

The etiology of the disease is complex and diverse.The over-activation of JAK-STAT signaling pathway plays Magnetron a significant role in the pathogenesis of autoimmune diseases.In this article, we summarize the mechanism of the JAK-STAT pathway and its role in Denim Shorts the occurrence and development of IEI and autoimmune diseases, suggesting that the hyperactivation of JAK-STAT pathway having connection with IEI and autoimmune diseases.

Meanwhile, we hope to make IEI a good model to study the pathogenesis of autoimmune diseases and to provide new ideas and directions for the clinical treatment of autoimmune diseases.